Correlates the Biochemical Markers of Ovarian Neoplasm, Experience From A Tertiary Care Setting in A City Of India

Most ovarian neoplasms are benign, epithelial types are commonest. There is no regular screening test for detecting malignant ovarian neoplasm, most patients remain asymptomatic until late stages. About 80% of malignant ovarian neoplasm present in stage 3 and 4 with 15% 5 year survival rate. To find out frequency of different types of ovarian neoplasm among women aged 15-60 years and correlates ovarian neoplasm among benign and malignant neoplasms and compare levels of tumour markers among subjects with benign and malignant neoplasms. A Cross sectional descriptive study conducted in a tertiary care setting, city of Eastern India, women aged 1560 years with ovarian neoplasm. 131 selected study subjects interviewed with predesigned schedule, levels of tumour markers CA-125 and β-hCG estimated. Final analysis done on 112 histopathologically confirmed cases. Data analyzed in SPSS version 16.0. Most ovarian neoplasms were benign (65%). Histopathologically commonest serous cyst adenoma (25%), serous cyst adenocarcinoma (23.22%). Malignant neoplasm had significant association with urban residence (56.41%) (p=0.048), menopause (53.84%) (p=0.005) and serum CA-125(p=0.0001). Patients with gynaecological comorbidities found suffering more benign ovarian neoplasm (p=0.01). Postmenopausal women have more chance of having malignant ovarian neoplasm than benign neoplasm.